Table 1.

Results from full-text articles

Date	Study	Context	L	N	Age	Type	Stage	Uniqueness of study	Findings
Jan 2004	Extermann M et al.[12]	Single center pilot study assessing role of CGA in oncological treatment.	3	15	≥70	Breast	55% Stage I, 45% Stage II	QOL was measured by the Functional Assessment of Cancer Treatment-Breast tool. Functional status was assessed by ADL, IADL, ECOG-PS, GDS, MNA, Charlson Comorbidity Index, CIRS-G.	CGA with follow-up can extend quality of life in these patients from treatment and prognostic aspects.
Nov 2005	Hurria A et al.[13]	Feasibility study concerning a cancer-specific CGA.	3	43	≥65	25% breast, 18% CRC, 38% lung, 20% lymphoma	5% Stage 1, 10% Stage II, 18% Stage III, 68% Stage IV	Specifies use of ADL, IADL, KPS, Timed Up and Go, BOMC, HADS, MOS, Seeman and Berkman Social Ties, BMI, % unintentional weight loss in the last six months in a CGA that is specific for cancer. Specifies ethnicity of participants as 90% white, 10% black.	The cancer-specific CGA can be completed by the majority of patients to provide reliable and valid results.
Dec 2006	Pope, D et al.[14]	Study of Geriatric Assessment in older patients with operable cancer.	3	460	>70	216 breast, 146 GIT, 71 GUT, 27 other	For breast cancer: 48% Stage 1, 39.3% Stage 2, 12.7% Stage 3.	Specified use of PACE, an advanced form of CGA using BFI, ECOG-PS, IADL, GDS, MMSE, ASA and SIC.	Geriatric Assessments can be a useful tool in evaluating fitness for surgery in the older cancer patient.
Jan 2008	Albrand, G and Terret, C [15]	Single-center review of assessment of breast cancer in the older.	3	76	>70	Breast	Primary	Specific for breast cancer. Specifies use of CIRS-G score as part of CGA.	CGA should be performed before any treatment decisions are made. More trials need to be conducted involving older patients, to determine efficacy of chemotherapy in older breast cancer patients.
March 2010	Gironés, R et al.[16]	Single-center experience of use of CGA for breast cancer patients.	3	91	>70	Breast	26% Stage I, 58% Stage II, 16% Stage III	Specific for breast cancer, specifying use of ADL, IADL, ECOG PS, GDS, Charlson comorbidity index, BMI, Balducci criteria for frailty in CGA.	Function and independence in older breast cancer patients with co-morbidities can be preserved by use of CGA. CGA is often too time consuming to be practically assessed in an oncology setting.
Jul 2010	Molina- Garrido, M and Guillén-Ponce, C [17]	Single center comparison of two frailty screening tools and CGA.	3	41	≥65	Breast	53.7% Stage I, 41.5% Stage II, 2.4% Stage III, 2.4% Stage IV	Specific for breast cancer. Specifies use of ADL, IADL, Charlson comorbidity index, Pfeiffer test for cognition and NSI.	Patients who had a score indicative of frailty had scores in CGA suggesting poorer physical function, malnutrition and cognition.
Jul 2011	Barthélémy, P et al.[18]	Single center retrospective review of recommendation of adjuvant chemotherapy to older breast cancer patients	3	192	>70	Breast	Primary	Specific for primary breast cancer only. Specifies use of ADL, IADL, ECOG PS, GDS, BMI, MNA, CIRS-G.	Some components of CGA may be able to determine its use in predictability of chemotherapy use.
Jul 2011	Lazarovici, C et al.[19]	Single center investigation into what components of CGA correlate to need for geriatric referral within older cancer patients	3	65	≥71	Breast (29%), lung (24.6%), colorectal (7.6%)	60% had metastatic disease	Specifies use of ADL, IADL, MMSE, BMI, CIRS-G	Patients who had CGA before they had made their cancer treatment decision were more likely to receive an altered treatment plan.
Aug 2011	Hurria, A et al.[20]	A multicenter trial to assess use of CGA in determining chemotherapy toxicity in older cancer patients	3	700	≥65	Lung (29%), GI (27%), gynaecological (17%), breast (11%), genitourinary (10%), or other (6%)	5% Stage I, 12% Stage II, 22% Stage III, 61% Stage IV	Same CGA format used in previous study by Hurria et al.[13]	Some components of the CGA can be used to assess potential toxicity of chemotherapy in this group of older cancer patients.

ADL, Activities of Daily Living; ASA, American Society of Anesthesiologists grade; BFI, Brief Fatigue Inventory; BMI, Body Mass Index; BOMC, Blessed-Orientation Memory Concentration test; CGA, Comprehensive Geriatric Assessment; CIRS-G, Cumulative Illness Rating Scale – Geriatrics; CRC, Colorectal cancer; ECOG-PS, Eastern Cooperative Oncology Group Performance Status Scale; GDS, Geriatric Depression Scale; GIT, Gastro-intestinal Tract; GUM, Genito-urinary Tract; HADS, Hospital Anxiety and Depression Scale; HHC, Home Health Care; IADL, Instrumental Activities of Daily Living; KPS, Karnofsky Performance Status; L, Level of evidence; MMSE, Mini-mental state examination; MNA, Mini Nutritional Assessment; MOS, Medical Outcomes Study; N, Number of patients; NCI, National Cancer Institute; NIA, National Institute on Aging; NSI, Nutrition Screening Initiative; PACE, Pre-operative assessment of cancer in the older; QOL, Quality of Life; SIC, Satariano’s Index of Co-morbidities.