Table 1.
BCL-2 family proteins
| BH3 only pro-apoptotic proteins | Multi-domain pro-apoptotic | Anti-apoptotic proteins |
|---|---|---|
|
Activators |
|
|
| BIM |
BAK |
BCL-2 |
| BID |
BAX |
BCL-XL |
| PUMA |
BOK |
BCL-W |
| |
|
MCL-1 |
|
Sensitizers |
|
BFL/BCL-2A1 |
| NOXA |
|
BCL-B |
| BAD |
|
|
| BMF |
|
|
| HRK |
|
|
| BIK |
|
|
| BNIP3 |
Of the BH3 only proteins, BID, BIM and possibly PUMA are considered apoptosis activators and the others as apoptosis sensitizers. BOK is an apoptosis effector expressed primarily in the ovary.