Table 6.
Biomarker |
Coll 2-1 (nM) n = 21 |
Coll 2-1 NO2 (nM) n = 21 |
CS-846 (ng/mL) n = 20 |
CP II (ng/mL) n = 21 |
IL-6 (pg/mL) n = 18 |
---|---|---|---|---|---|
mean ± SD | |||||
V2 (baseline) |
127 ± 62 |
0.44 ± 0.29 |
92 ± 24 |
1040 ± 518 |
5825 ± 21720 |
V6 (D84) |
116 ± 37 |
0.38 ± 0.18 |
93 ± 21 |
1000 ± 646 |
162 ± 405 |
Change |
-11 ± 78 |
-0.06 ± 0.41 |
1 ± 17 |
-41 ± 865 |
-5663 ± 21769 |
|
correlation coefficients (biomarkers change vs pain change) |
||||
Pearson |
-0.395 |
-0.412 |
-0.021 |
-0.469 |
-0.086 |
|
p = 0.0766 |
p = 0.0637 |
p = 0.9296 |
p = 0.0319 |
p = 0.7354 |
Spearman |
-0.274 |
-0.262 |
0.026 |
-0.319 |
0.151 |
p = 0.2287 | p = 0.2512 | p = 0.9122 | p = 0.1584 | p = 0.5500 |
mL = milliliter; n = number of patients; ng = nanogram; nM = nanomolar; pg = picogram; SD = standard deviation.
Note: Only patients with both a baseline value and a time point value are summarized at Visit 6; Correlation coefficients between the absolute change of each biomarker and the absolute change of pain from V2 and V6.