Table 2.
Action potential features of experimental and simulated action potentials
| |
Early |
Late |
Delta % |
|||
|---|---|---|---|---|---|---|
| Exp | Sim | Exp | Sim | Exp | Sim | |
| APD 30 (ms) |
117 (107÷132) |
121 |
163 (84÷256) |
165 |
+ 40 |
+ 36 |
| APD 50 (ms) |
169 (149÷184) |
163 |
258 (148÷374) |
224 |
+ 53 |
+ 37 |
| APD 70 (ms) |
205 (181÷219) |
191 |
325 (179÷465) |
283 |
+ 59 |
+ 48 |
| APD 90 (ms) |
229 (216÷241) |
225 |
419 (223÷506) |
350 |
+ 83 |
+ 56 |
| Vmax (mV/s) |
4610 (3308÷5612) |
4123 |
5566 (5198÷7047) |
5620 |
+ 42 |
+ 36 |
| MDP (mV) |
-55 (-62÷-37) |
-76 |
-51 (-62÷-42) |
-73 |
-7 |
- 4 |
| DDR (mV/s) |
14.4 (11.1÷28.4) |
9.7 |
9.9 (8.0÷11.1) |
7.1 |
- 31 |
- 27 |
| F (bpm) | 27 (23÷53) | 29 | 22 (20÷29) | 24 | - 17 | - 17 |
Delta %, Late VS Early; APD, action potential duration; Vmax maximum upstroke velocity; MDP maximum diastolic potential; DDR diastolic depolarization rate; F frequency. Data reported as median and interquartile. All the experimental action potential features were measured on hESC-CM AP at the Early and Late stage [50].