Table 3. Associations of the individual obesity-susceptibility SNPs and the GPS¹ with adiposity-related traits² in young adulthood (HUNT3)³.

				Z-scores BMI				Z-scores WC
SNP	Chrom	Nearest gene	B	CI (95%)	P-value	Literature		B	CI (95%)	P-value	Literature
rs2815752	1	NEGR1	−.028	−.098, .042	.436		0.024d	−.007	−.077, .063	.845	0.022d
rs6548238	2	TMEM18	.018	−.075, .125	.699		0.070d	.017	−.076, .109	.726	0.050d
rs10938397	4	GNPDA2	−.001	−.071, .069	.976		0.045d	−.013	−.083, .057	.719	0.039d
rs987237	6	TFAP2B	.022	−.067, .111	.624		−	−.035	−.124, .054	.439	0.035e
rs4074134	11	BDNF	.054	−.034, .142	.226		0.055d	.072	−.016, .159	.109	0.049d
rs10838738	11	MTCH2	.048	−.022, .117	.182		0.021d	.062	−.007, .131	.080	0.011d
rs1121980	16	In FTO	.086	.017, .156	.015		0.086d	.071	.002, .140	.045	0.080d
rs17782313	18	MC4R	.103	.025, .181	.010		0.047d	.069	−.009, .147	.082	0.042d
rs11084753	19	KCTD15	.062	−.014, .138	.110		0.016d	.047	−.028, .123	.220	0.024d
GPS			.041	.015, .067	.002		0.039d	.033	.008, .059	.011	0.033d

¹The genetic predisposition score (GPS) is the sum of effect alleles from each of the nine individual SNPs.

²Sex specific z-scores of BMI and waist circumference in young adulthood.

³Number of participants: for individual SNPs = 1643 and for GPS = 1634 (those missing more than 3 SNPs excluded).

The linear regression models were adjusted for age regarding BMI and additionally also for height regarding WC, assuming an additive effect.

Pregnant participants were excluded.

Chrom: chromosome.

Comparable effect sizes in the literature:

^dLi et al. [35];

^eLindgren et al. [19].