Table 2. Univariate analysis of the impact of HLA Class I alleles on HIV-1 viral load in 2031 HIV-1 C-clade infected Southern African subjects (q<0.2).
| HLA allelea | Phenotypic frequency (%) | Weightb | p-value | q-value |
| B*15:01 | 0.6 | 0.65 | 3.01E-02 | 0.11 |
| B*57 | 6.2 | 0.63 | 8.42E-12 | 7.24E-10 |
| Cw*12 | 3.2 | 0.45 | 4.48E-04 | 3.86E-03 |
| A*74 | 10.2 | 0.34 | 1.03E-05 | 1.88E-04 |
| B*13 | 2.8 | 0.32 | 1.96E-02 | 8.01E-02 |
| B*39 | 3.6 | 0.32 | 7.44E-03 | 4.00E-02 |
| Cw*18 | 11.6 | 0.29 | 2.49E-05 | 3.57E-04 |
| B*81 | 10.0 | 0.28 | 1.60E-04 | 1.72E-03 |
| B*58:01 | 10.6 | 0.26 | 3.81E-04 | 3.65E-03 |
| A*33 | 4.8 | 0.23 | 3.12E-02 | 0.11 |
| B*14 | 7.1 | 0.19 | 3.45E-02 | 0.12 |
| B*42 | 22.8 | 0.18 | 1.12E-03 | 8.35E-03 |
| A*01 | 7.2 | 0.17 | 5.23E-02 | 0.16 |
| Cw*17 | 24.9 | 0.15 | 6.34E-03 | 3.63E-02 |
| Cw*08 | 10.9 | 0.14 | 6.05E-02 | 0.16 |
| Cw*04 | 23.6 | 0.14 | 1.33E-02 | 5.74E-02 |
| B*44 | 16.6 | 0.13 | 3.13E-02 | 0.11 |
| B*15:10 | 16.2 | -0.11 | 7.00E-02 | 0.18 |
| B*15:03 | 16.9 | -0.11 | 6.01E-02 | 0.16 |
| Cw*02 | 21.1 | -0.12 | 3.68E-02 | 0.12 |
| A*03 | 11.2 | -0.13 | 6.00E-02 | 0.16 |
| A*66 | 8.3 | -0.21 | 9.31E-03 | 4.45E-02 |
| Cw*16 | 11.6 | -0.21 | 2.42E-03 | 1.60E-02 |
| B*08 | 10.6 | -0.23 | 1.54E-03 | 1.10E-02 |
| A*68:01 | 6.4 | -0.26 | 4.24E-03 | 2.60E-02 |
| B*45 | 9.6 | -0.30 | 1.42E-04 | 1.72E-03 |
| Cw*06 | 29.4 | -0.31 | 4.54E-10 | 1.30E-08 |
| B*58:02 | 22.0 | -0.35 | 9.71E-11 | 4.18E-09 |
| A*80 | 1.6 | -0.35 | 4.30E-02 | 0.14 |
| B*18 | 6.1 | -0.42 | 1.09E-05 | 1.88E-04 |
a
Alleles in bold and underlined are those that remain significant with a more stringent FDR of q<0.05.
b
Alleles with a positive weight (above double line) are associated with statistically significant disease control; alleles with a negative weight (below double line) are associated with hazardous (detrimental) outcome.