Table 5. Multivariate analysis of pairs of HLA Class I alleles, showing pairs associated with hazardous (detrimental) impact on HIV-1 disease control with respect to decline in CD4+ T cell count and/or increased viral load (q<0.2).
| HLA-1a | HLA-2 | Frequency of pair (%) | Linkageb (p-value) | Weight of pair | p-value for pair | q-value for pair |
| B*58:02 | Cw*16 | 1.4 | N/S | −1.17 | 2.00E-05 | 2.97E-03 |
| B*45 | B*58:02 | 1.3 | N/A | −1.03 | 6.80E-04 | 7.21E-02 |
| Cw*06 | Cw*16 | 1.9 | N/A | −0.93 | 2.00E-05 | 2.97E-03 |
| Cw*02 | Cw*06 | 3.7 | N/A | −0.71 | 1.12E-03 | 1.04E-01 |
| B*45 | B*58:02 | 1.3 | N/A | −0.68 | 2.60E-04 | 1.98E-01 |
| B*18 | Cw*16 | 0.5 | N/S | −0.66 | 1.30E-03 | 1.38E-01 |
| B*45 | Cw*06 | 3.2 | N/S | −0.57 | 2.84E-03 | 1.76E-01 |
| A*68:01 | Cw*02 | 1.3 | N/S | −0.37 | 2.48E-03 | 1.76E-01 |
| A*68:01 | B*15:03 | 1.1 | N/S | −0.37 | 2.58E-03 | 1.76E-01 |
| A*23 | B*41 | 0.6 | N/S | −0.26 | 5.90E-03 | 2.00E-01 |
| A*23 | B*15:03 | 4.0 | N/S | −0.23 | 4.00E-03 | 1.98E-01 |
| B*08 | B*18 | 0.4 | N/A | −0.21 | 2.00E-05 | 4.95E-03 |
| B*18 | B*45 | 0.4 | N/A | −0.21 | 1.24E-03 | 4.82E-02 |
| B*15:10 | B*58:02 | 2.4 | N/A | −0.17 | 4.30E-03 | 2.00E-01 |
| A*66 | Cw*06 | 5.2 | 9.15E-22 | −0.13 | 4.36E-03 | 2.00E-01 |
| A*30 | A*68:01 | 1.1 | N/A | −0.13 | 5.12E-03 | 2.00E-01 |
| B*15:10 | Cw*06 | 3.0 | 4.02E-07 | −0.13 | 3.82E-03 | 2.00E-01 |
a
Pairs in bold and underlined are those that remain significant with a more stringent q<0.05.
b
Linkage is reported if relevant; otherwise designated as N/S = not significant (corrected for multiple comparisons; only values p<1.9E-05 are reported), or N/A = not applicable (two alleles at same locus).