Figure 1. The flavivirus E glycoprotein fusion loop and hydrophobicity plots of the fusion peptides.

(A) The crystallographic structure of West Nile virus E protein (PDB ID 2HG0) and the schematic representation and sequence of the two fusion peptides of flaviviruses studied in this work. FLA_G has a Gly residue (red) in position 104 of glycoprotein E, while FLA_H presents a His residue (blue). Trp101, Gly104 and His104 are indicated in bold, red and blue, respectively. The conserved amino acids are underlined. (B) Hydrophobicity plots for the fusion peptides FLA_G (solid line) and FLA_H (dashed line) were elaborated using the Wimley-White hydrophobicity scale.