Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Oct 19;7(10):e48273. doi: 10.1371/journal.pone.0048273

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

PMC Copyright notice

The top 10 biofunctions pathways derived from IPA analyses of differentially expressed genes in the brain of Npc1 ^−/− mice and ranked by ‘p values’ (lowest to highest) are shown. The numbers along each bar represent the total number of differentially expressed genes (both up and down regulated) categorized in each biofunction (see also Table S4). A total of 53 genes (45 up and 8 down regulated) associated with immune response were enriched in the brain of Npc1 ^−/− across all time points (B) Bar diagram shows the top 10 biofunctions enriched in the liver of Npc1 ^−/− compared to Npc1 ^+/−. A total of 209 genes (159 up and 50 down regulated) associated with the immune response were enriched in the liver of Npc1 ^−/− across all time points (see also Table S4). (C) Bar diagram shows the top 10 biofunctions enriched in the spleen of Npc1 ^−/− compared to Npc1 ^+/−. A total of 58 genes (49 up and 9 down regulated) associated with the immune response were enriched in the spleen of Npc1 ^−/− across all time points (see Table S4).