Table 1. Top 20 up regulated genes in brain of Npc1−/− mice across the life span (20–84 days).
| Genes | Fold up regulation |
| Lyz1: lysozyme 1 | 12.2 |
| Clec7a: C-type lectin domain family 7, member a | 11.16 |
| Gm11428: predicted gene 11428 | 10.32 |
| Lyz2: lysozyme 2 | 9.62 |
| Gp49a : glycoprotein 49 A | 8.44 |
| Itgax: integrin alpha X | 7.09 |
| Mpeg1: macrophage expressed gene 1 | 5.93 |
| Cd84: CD84 antigen | 5.87 |
| Gpnmb: glycoprotein (transmembrane) nmb | 5.34 |
| H19: H19 fetal liver mRNA | 4.9 |
| Fcgr2b: Fc receptor, IgG, low affinity IIb | 4.38 |
| Ms4a7: membrane-spanning 4-domains, subfamily A, member 7 | 4.32 |
| Tnfaip2: tumor necrosis factor, alpha-induced protein 2 | 4.32 |
| Cd68: CD68 antigen | 4.26 |
| Ifit1: interferon-induced protein with tetratricopeptide repeats 1 | 4.25 |
| Gfap: glial fibrillary acidic protein | 4.14 |
| C4b: complement component 4B (Childo blood group) | 4.14 |
| C3ar1: complement component 3a receptor 1 | 3.99 |
| Usp18: similar to ubiquitin specific protease UBP43 | 3.91 |
| Trem2: triggering receptor expressed on myeloid cells 2 | 3.88 |
Genes marked in bold are related to innate immunity and the genes marked in bold and also underlined are innate immunity genes catalogued by InnateDB.