Table 2. Top 20 up regulated genes in liver of Npc1−/− mice across three age groups (20–71 days).
| Genes | Fold up regulation |
| Mmp12: matrix metallopeptidase 12 | 80.37 |
| Il7r: interleukin 7 receptor | 55.29 |
| Gpnmb: glycoprotein (transmembrane) nmb | 48.32 |
| Pou3f1/Oct-6 | 39.5 |
| Lgals3: lectin, galactose binding, soluble 3 | 36.39 |
| Egr2: early growth response 2 | 25.78 |
| Capg: capping protein (actin filament), gelsolin-like | 25.69 |
| Clec4d: C-type lectin domain family 4, member d | 25.15 |
| Nupr1: nuclear protein 1 | 23.94 |
| Gpr137b : G protein-coupled receptor 137B | 23.23 |
| Klra3/9 : killer cell lectin-like receptor, subfamily A, member 3/9 | 22.81 |
| Clec7a: C-type lectin domain family 7, member a | 21.49 |
| Camp: cathelicidin antimicrobial peptide* | 21.32 |
| Mm.138637.1 | 20.92 |
| Slamf7: SLAM family member 7 | 19.18 |
| Mm.201472.1 | 17.34 |
| Speg: SPEG complex locus | 16.02 |
| Bcl2a1a/b/d: B-cell leukemia/lymphoma 2 related protein A1a/b/d | 15.61 |
| Odz4: odd Oz/ten-m homolog 4 (Drosophila) | 15.51 |
| Ms4a7: membrane-spanning 4-domains, subfamily A, member 7 | 15.08 |
Genes marked in bold are related to innate immunity and the genes marked in bold and also underlined are innate immunity genes catalogued by InnateDB.