Table 3. Top 20 up regulated genes in spleen of Npc1−/− mice across three age groups (20–71 days).
| Genes | Fold up regulation |
| Atp6v0d2: ATPase, H+ transporting, lysosomal V0 subunit D2 | 58.08 |
| Gpnmb: glycoprotein (transmembrane) nmb | 19.98 |
| Hal: histidine ammonia lyase | 10.06 |
| Clec7a: C-type lectin domain family 7, member a | 9.7 |
| Gm11428: predicted gene 11428 | 8.84 |
| Trim29: tripartite motif-containing 29 | 8.65 |
| Atf3: activating transcription factor 3 | 8.37 |
| Mmp12: matrix metallopeptidase 12 | 8.24 |
| Ahnak2: AHNAK nucleoprotein 2 | 7.64 |
| Dnahc2: dynein, axonemal, heavy chain 2 | 7.55 |
| Cdkn1c: cyclin-dependent kinase inhibitor 1C (P57) | 6.84 |
| Mm.138637.1 | 6.23 |
| Ms4a7: membrane-spanning 4-domains, subfamily A, member 7 | 6.21 |
| Fabp5: fatty acid binding protein 5 | 6.1 |
| 9430019H13Rik: RIKEN cDNA 9430019H13 gene | 5.88 |
| Msr1: macrophage scavenger receptor 1 | 5.86 |
| Anpep: alanyl (membrane) aminopeptidase | 5.05 |
| Elane: elastase, neutrophil expressed | 4.68 |
| F10: coagulation factor X | 4.56 |
| Ms4a3: membrane-spanning 4-domains, subfamily A, member 3 | 4.52 |
Genes marked in bold are related to innate immunity and the genes marked in bold and also underlined are innate immunity genes catalogued by InnateDB.