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. 2012 Oct 19;7(10):e45509. doi: 10.1371/journal.pone.0045509

Figure 6. Cyclosporin-A and rapamycin treatment prevents systemic activation and proliferation of human CD4+ and CD8+ T cells in the huPBL-SCID/skin allograft mouse model.

Figure 6

A. Enumeration of CD4+ and CD8+ cell populations by flowcytometry in peripheral blood 21 days after infusion of huPBMC without (white bars) or with CsA (black bars) and Rapa. Summarized flowcytometry data are presented (n = 6). B. Flowcytometry of Ki67 in human CD4+ of CD8+ cells in peripheral blood 21 days after infusion of huPBMC without (white bars) or with CsA and Rapa (black bars). Summarized data of n = 6 are shown. C. Flowcytometry of CD45RO and CD45RA expression on human CD3+ T cells in peripheral blood after infusion of huPBMC without (white bars) or with CsA and Rapa (black bars). Summarized data of n = 6 are shown.