Figure 2. HIV-1 RNA (log₁₀ copies/mL) median change from Day 1 to Day 29.

Statistically significant (P<.001) HIV-1 RNA reductions were seen in each of the five VS411 dose arms with a median reduction in HIV-1 RNA across combined study arms at Day 29 of −1.47 log₁₀. There was a trend toward greater reductions with increasing doses of both didanosine and hydroxycarbamide. Only two of 58 evaluable subjects (3%) achieved HIV-1 RNA reductions to <50 copies/mL by Day 29.