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. 2012 Oct 19;7(10):e47485. doi: 10.1371/journal.pone.0047485

Figure 4. CD4+ and CD8+ T cells co-expressing HLA-DR and CD38.

Figure 4

In a sub-study of 32 of the 56 subjects completing VS411 for 28 days, rapid and statistically significant reductions were seen in the percentage of CD4+ (A) and CD8+ (B) cells co-expressing the two markers of cellular activation, CD38 and HLA-DR. After 28 days of VS411 treatment, the median percentage of CD4+ and CD8+ T cells co-expressing the two markers (C) decreased by 28.9% (from 6.09% to 4.33%) and 34.4% (from 25.87% to 16.98%), respectively (P<.005). These statistically significant reductions were obtained despite the fact that VS411 did not attain maximal suppression of HIV-1 RNA, suggesting the effect was due to the HALT component of this AV-HALT combination. In (A) and (B) the grey boxes span the 25th and 75th percentile values. The error bars span the 10th and the 90th percentile values. Each midline represents the median value. The dots represent individual observations below the 10th and above 90th percentile values.