Table 6. Changes in markers of excessive immune system activation after 28 days of treatment with VS411.
CD3+ subset (n = 32) | Baseline (mean ± SDa) | Day 29 (mean ± SD) | % Reduction | P value |
Ki-67% | 3.1±1.7 | 2.2±0.9 | 29.0 | <.005 |
PD-1% | 15.3±6.1 | 11.3±5.0 | 26.1 | <.005 |
CD38% | 58.5±14.8 | 52.8±14.2 | 9.7 | <.005 |
HLA-DR % | 27.5±10.1 | 22.2±7.5 | 19.3 | <.005 |
SD = Standard Deviation.