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. 2012 Nov;343(2):497–508. doi: 10.1124/jpet.112.196071

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Fig. 1. — Dose-dependent effect of CBLB502 on 30-day survival of lethally irradiated mice. a, Kaplan-Meier curves illustrating mouse survival for 30 days after TBI. Female ICR mice (12/group) were injected intramuscularly with vehicle or one of the indicated doses of CBLB502 and irradiated with 10 Gy of TBI 30 min later. b, CBLB502 dose response of 30-day survival in the same study as shown in a, with filled markers indicating statistically significant difference versus vehicle control group (p < 0.05 by two-tailed Fisher's exact test). c, Kaplan-Meier curves illustrating mouse survival for 30 days after TBI. Forty female C57BL/6J mice per group were irradiated with 9.5 Gy of TBI and injected subcutaneously with either vehicle or the indicated doses of CBLB502 24 h later. d, CBLB502 dose response of 30-day survival in the same study shown in c, with filled markers indicating statistically significant difference versus vehicle control group (p < 0.05 by two-tailed Fisher's exact test).