Fig. 5.

Influence of G-CSF or IL-6 neutralization on the radiomitigative efficacy of CBLB502 in mice. a, experimental scheme. Groups of 40 C57BL/6J female mice were exposed to 9 Gy of TBI. At +22 h relative to irradiation, the mice were injected intraperitoneally with anti-G-CSF, anti-IL-6, or control IgG antibodies and then injected intravenously with 60 μg/kg CBLB502 2 h later. The vehicle control group received 9 Gy of TBI and intravenous injection of the vehicle at +24 h. b, Kaplan-Meier curves illustrating mouse mortality kinetics for 30 days after TBI.