TABLE 1.
Single-channel kinetics
Numbers of patches selected as being suitable for burst analysis were as follows: ACh, n = 3; ACh + TQS, n = 11; 4BP-TQS, n = 13; and ACh + 4BP-TQS, n = 7. Data are means ± S.E.M.
| Agonist | Open Time | Shut Time | Open Probability | Burst Length | Open Time within Burst |
|---|---|---|---|---|---|
| ms | |||||
| ACh (n = 9) | 1.49 ± 0.28§ | 4113 ± 1419§§§ | 0.0004 ± 0.0015§ | 3.28 ± 2.24§ | 2.00 ± 1.26 |
| ACh + TQS (n = 14) | 24.7 ± 5.8††† | 379 ± 103*** | 0.13 ± 0.04††† | 165 ± 55 | 141 ± 42 |
| 4BP-TQS (n = 20) | 245 ± 68* | 532 ± 184*** | 0.32 ± 0.09* | 1228 ± 364* | 1207 ± 360 |
| ACh + 4BP-TQS (n = 8) | 330 ± 56** | 590 ± 135*** | 0.36 ± 0.09††† | 3099 ± 754**,‡ | 2845 ± 745**,§ |
Significant differences (determined by ANOVA) to ACh (* P < 0.05; ** P < 0.01; *** P < 0.001) or to 4BP-TQS (§ P < 0.05; §§§ P < 0.001) are indicated. Otherwise, significant differences determined by pairwise comparisons to ACh (††† P < 0.001) or to 4BP-TQS (‡ P < 0.05) are indicated.