TABLE 1.
Effect of EGCG (10 nM) on Ca2+ kinetics and sarcomere shortening in ventricular myocytes
n = 25.
| Vehicle (n = 31) | EGCG (n = 21) | |
|---|---|---|
| Ca2+ transient | ||
| Diastolic signal (Fratio) | 1.31 ± 0.04 | 1.35 ± 0.01 |
| Peak height (Fratio) | 0.26 ± 0.03 | 0.64 ± 0.15* |
| Time to peak (ms) | 26 ± 2 | 45 ± 4* |
| Time to 50% peak (ms) | 9 ± 1 | 10 ± 1 |
| τ (ms) | 340 ± 27 | 284 ± 25 |
| Caffeine peak height (Fratio) | 0.63 ± 0.1 | 0.92 ± 0.1* |
| Caffeine τ (s) | 1.72 ± 0.10 | 2.31 ± 0.17* |
| Cell shortening | ||
| Diastolic sarcomere length (μm) | 1.72 ± 0.01 | 1.75 ± 0.02 |
| % fractional shortening | 2.15 ± 0.33 | 5.61 ± 0.70* |
| Time to peak (ms) | 151 ± 12 | 119 ± 7* |
| Time to 50% peak (ms) | 43 ± 4 | 38 ± 4 |
*
p < 0.05 versus vehicle.