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Effects of single point mutations of mGlu5 on MPEP inhibition of mGlu5-mediated Ca2+ mobilization in response to glutamate. Translocation of glutamate concentration-response curves in the presence of the indicated concentrations of MPEP in polyclonal HEK293A cells expressing wild-type (A), Y658V (B), L743V (C), or A809V (D) mGlu5 was determined. Data represent the mean ± S.E.M. from at least three independent determinations. Error bars not shown lie within the dimensions of the symbols.
