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EMSAs using mouse liver nuclear extracts show that specific arylstibonic acids inhibit the binding of C/EBP or CRE-containing DNA. A, the 32P-labeled C/EBP (top) or CRE (bottom) DNA probe (lane 1) was incubated with mouse liver nuclear extracts in the absence (lane 2) or presence (lanes 3–27) of 100 μM arylstibonic acids. B, competition assay using nuclear extracts and three unlabeled DNA probes at 100-fold molar excess.
