Table 4.
Sex differences in renal transporter expression between male and female rodents.a
| Transporter | Mice | Rats | References |
|---|---|---|---|
| Uptake | |||
| Oatplal | M > F | M > F | (153,163,164) |
| Oatp1a6 | M = F | M = F | (163,164) |
| Oatp2b1 | M = F | N.D. | (163) |
| Oatp3a1 | M > F | N.D. | (153,163) |
| Oatp4c1 | M > F | N.D. | (136,163) |
| Oatl | M > F | M > F | (8,130,131,133,141) |
| Oat2 | F ≥ M | F > M | (130-133,141) |
| Oat3 | F ≥ Mb | M ≥ F | (8,130,131,133,141) |
| Oat5 | F > M | F > M | (135,136) |
| Urat1 | M > F | N.D. | (136) |
| Oct1 | M = F | F > M | (22,25) |
| Oct2 | M > F | M > F | (22,25,141,144) |
| Oct3 | M = F | M = F | (22,25) |
| Octn1 | M = F | M = F | (22,25) |
| Octn2 | M = F | M = F | (22,25) |
| Pept1 | M = F | M = F | (165) |
| Pept2 | M = F | F > M | (165) |
| Efflux | |||
| Mate1 | M > F | N.D. | (37) |
| Mdr1b | F > M | N.D. | (53) |
| Bcrp | M = F | M > F | (166) |
| Mrp1 | M = F | N.D. | (71) |
| Mrp2 | M = F | N.D. | (71) |
| Mrp3 | F > M | N.D. | (71,146) |
| Mrp4 | F > M | N.D. | (71,146) |
| Mrp5 | M = F | N.D. | (71) |
| Mrp6 | M = F | N.D. | (71) |
a
The mRNA and/or protein expression of transporters in kidneys of adult male (M) and female (F) rats or mice. ND denotes transporter expression that was not determined.
b
Compared to male counterparts, elevated Oat3 mRNA was higher in female 129 J mice, but not female C57BL/6 mice.