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Cranial MRI of patients. First column: Rostral axial T1 weighted images show simplified gyral pattern, severe microcephaly, and different degree of ventriculomegaly, suggestive for cerebral atrophy. Second column: Caudal axial T1 weighted images showing brain atrophy and simplified gyral pattern. Third column: Sagittal images showing severely reduced volume of corpus callosum and cerebellar vermis hypoplasia.
