Table 4.

DCE MRI Parameters and Tumor Response by RECIST 1.0

	Time point	Ampa	kepb	kelc	% Change in primary tumord	Radiographic responsee by RESIST
Patient 1g	Week 0	1.90	1.53	0.07	46% ↓	PR
	Week 2	1.71	1.19	0.01
Patient 2h	Week 0	1.44	1.89	0.28	0%	PDe
	Week 2	1.58	0.93	0.04
Patient 3i	Week 0	1.56	1.30	−0.11	16% ↑	PDf
	Week 2	1.71	0.76	0.02
Patient 4j	Week 0	1.88	1.10	−0.13	12% ↓	SD
	Week 2	2.99	0.62	−0.06

^aAmp= amplitude [automatic unit]

^bk_ep=exchange rate [/min]

^ck_el=elimination rate [/min]

^dAccording to RECIST 1.0

^eProgressive disease at week 10 (liver metastases)

^fProgressive disease at week 5 (liver metastases)

^gPatient 1 in Table 3

^hPatient 2 in table 3

^gPatient 3 in table 3

^jPatient 11 in Table 3