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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Addict Biol. 2012 Jul 15;18(3):467–479. doi: 10.1111/j.1369-1600.2012.00466.x

Figure 2.

Figure 2

Effects of N/OFQ on anxiety-like behavior measured 3 weeks following termination of chronic ethanol (ethanol-dependent) or vehicle (nondependent) administration in (A) the elevated plus maze and (B) defensive burying tests. Overt anxiety-like behavior in ethanol-dependent rats no longer differed from that of nondependent rats in terms of either elevated plus maze or defensive burying performance (see zero dose, vehicle condition). As during the 1-week post-withdrawal test (Figure 1), N/OFQ produced anxiolytic-like effects at the high (2µg) dose in nondependent rats. In contrast, N/OFQ produced anxiogenic-like effects at doses of 1.0 µg (elevated plus maze, defensive burying) and 2 µg (elevated plus maze) in ethanol-dependent rats. * p < 0.05 vs. vehicle (0 dose) within the same group; § p < 0.05 vs. nondependent.