Fig.2.

Extracellular VACV immunomodulators CrmE and A41 inhibit TNFα and CC chemokines respectively. (A) The structure of CrmE. In the left panel CrmE is shown colour ramped from blue (N terminus) to red (C terminus), and in the right panel the domain structure of CrmE is shown in a ribbon representation with CRDs 1–3 coloured blue, green and red, respectively. (B) The structure of A41 (pale green) is shown superposed onto the vCCI of cowpox virus (CPXV, wheat) with conserved β strands forming the β sheets labelled. The view in the right panel is rotated 90° with respect to the left panel and the ‘2–4 loop’ present in vCCI’s is highlighted red and labelled.