Table 1.
Description | References | PDB ID | |
---|---|---|---|
Extracellular immunomodulators | |||
A41 | Chemokine inhibitor | Bahar et al. (2008) | 2VGA |
CPXV vCCI | Chemokine inhibitor | Carfi et al. (1999) | 1CQ3 |
Rabbitpox virus vCCI | Chemokine inhibitor (complex) | Zhang et al. (2006) | 2FIN |
ECTV vCCI | Chemokine inhibitor | Arnold and Fremont (2006) | 2GRK |
CrmE | TNF-α inhibitor | Graham et al. (2007) | 2UWI |
TPXV 2 | MHC-like TNF-α inhibitor | Yang et al. (2009) | 3IT8 |
IL-18 BP | Blocks IL-18 binding to IL-18R | Krumm et al. (2008) | 3F62 |
IFN-gamma BP | Blocks IFNγ - binding to IFN-γR | Nuara et al. (2008) | 3BES |
A39 | Semaphorin 7A mimic | Liu et al. (2010) | 3NVX |
Intracellular immunomodulators | |||
N1 | Bcl-2–like inhibitor of apoptosis and toll-like receptor signalling to NF-κB | Cooray et al. (2007); Aoyagi et al. (2007) | 2UXE 2I39 |
B14 | Bcl-2–like inhibitor of NF-κB | Graham et al. (2008) | 2VVY |
A52 | Bcl-2–like inhibitor of NF-κB | Graham et al. (2008) | 2VVW |
K7 | Bcl-2–like inhibitor of NF-κB and IFN-β | Oda et al. (2009) | 3JRV |
F1 | Bcl-2–like anti-apoptotic | Kvansakul et al. (2008) | 2VTY |
M11 | Bcl-2–like anti-apoptotic | Kvansakul et al. (2007) | 2JBY |
K3 | Inhibits PKR mediated phosphorylation of eIF2α | Dar and Sicheri (2002) | 1LUZ |
VH1 | Dephosphorylates STAT-1, blocks expression of IFN induced genes (ISGs) | Koksal et al. (2009) | 3CM3 |
Structures highlighted in bold were determined as part of SPINE2-Complexes.