Table 1.
Structures of poxvirus immunomodulators present in the PDB.
| Description | References | PDB ID | |
|---|---|---|---|
| Extracellular immunomodulators | |||
| A41 | Chemokine inhibitor | Bahar et al. (2008) | 2VGA |
| CPXV vCCI | Chemokine inhibitor | Carfi et al. (1999) | 1CQ3 |
| Rabbitpox virus vCCI | Chemokine inhibitor (complex) | Zhang et al. (2006) | 2FIN |
| ECTV vCCI | Chemokine inhibitor | Arnold and Fremont (2006) | 2GRK |
| CrmE | TNF-α inhibitor | Graham et al. (2007) | 2UWI |
| TPXV 2 | MHC-like TNF-α inhibitor | Yang et al. (2009) | 3IT8 |
| IL-18 BP | Blocks IL-18 binding to IL-18R | Krumm et al. (2008) | 3F62 |
| IFN-gamma BP | Blocks IFNγ - binding to IFN-γR | Nuara et al. (2008) | 3BES |
| A39 | Semaphorin 7A mimic | Liu et al. (2010) | 3NVX |
| Intracellular immunomodulators | |||
| N1 | Bcl-2–like inhibitor of apoptosis and toll-like receptor signalling to NF-κB | Cooray et al. (2007); Aoyagi et al. (2007) | 2UXE 2I39 |
| B14 | Bcl-2–like inhibitor of NF-κB | Graham et al. (2008) | 2VVY |
| A52 | Bcl-2–like inhibitor of NF-κB | Graham et al. (2008) | 2VVW |
| K7 | Bcl-2–like inhibitor of NF-κB and IFN-β | Oda et al. (2009) | 3JRV |
| F1 | Bcl-2–like anti-apoptotic | Kvansakul et al. (2008) | 2VTY |
| M11 | Bcl-2–like anti-apoptotic | Kvansakul et al. (2007) | 2JBY |
| K3 | Inhibits PKR mediated phosphorylation of eIF2α | Dar and Sicheri (2002) | 1LUZ |
| VH1 | Dephosphorylates STAT-1, blocks expression of IFN induced genes (ISGs) | Koksal et al. (2009) | 3CM3 |
Structures highlighted in bold were determined as part of SPINE2-Complexes.