Table 2.
Final parameter estimates (variability as CV, precision as RSE%) and bootstrap results (n= 200, stratified on study, precision as RSE%)
| Parameter | Parameter estimates (RSE%) | Bootstrap (RSE%) | ||
|---|---|---|---|---|
| CL/F pop. 1 (l h−1) | 3.12 | (5.10) | 3.16 | (6.0) |
| CL/F pop. 2 (l h−1) | 1.45 | (14.70) | 1.45 | (15.8) |
| Probability (%) of belonging to pop. 2 | 17.30 | (45.30) | 19.30 | (48.1) |
| V/F (l) | 105 | (4.90) | 105 | (5.4) |
| MTT (h) fed | 2.46 | (7.50) | 2.46 | (7.1) |
| MTT (h) fasted | 0.596 | (8.70) | 0.60 | (9.0) |
| F (%) when TB treatment | 61.30 | (8.70) | 61.70 | (8.7) |
| Proportional error (%) | 8.41 | (5.40) | 8.39 | (4.8) |
| BSV CL/F (%) | 24.90 | (13.90) | 23.90 | (16.0) |
| BSV F when TB treatment (%) | 34.10 | (27.00) | 31.20 | (33.2) |
| BOV F (%) | 26.90 | (9.60) | 26.50 | (10.7) |
| BOV MTT (%) | 64.00 | (9.10) | 63.30 | (9.1) |
The values of CL/F and V/F refer to a typical person of 42 kg fat-free mass and 70 kg body weight. BOV, between occasion variability; BSV, between subject variability; CL/F, oral clearance; F, bivalent; MTT, meant transit time; pop., population; TB, tuberculosis; V/F, apparent volume of distribution.