Figure 2.

Visual predictive check showing the 95% percentiles (dashed line) and 50th percentile (solid line) and their respective confidence intervals for the model predicted data of the total cohort for (A) 48 h after allopurinol dosing in the total cohort and (B) 48 h after allopurinol dosing in patients with varying degrees of renal impairment. Healthy, CL_Cr >60 ml min⁻¹; mild, CL_Cr 30–60 ml min⁻¹; moderate, CL_Cr 15–30 ml min⁻¹; severe, CL_Cr 0–15 ml min⁻¹