Figure 4.

The model predicted median (black lines) and 95% confidence intervals (grey lines) plasma concentrations of oxypurinol over time for patients being dosed with allopurinol according to the current dosing guidelines. Each panel depicts a patient with particular renal function receiving an allopurinol dose of (A) 350 mg day⁻¹ (CL_Cr= 120 ml min⁻¹), (B) 300 mg day⁻¹ (CL_Cr= 100 ml min⁻¹), (C) 250 mg day⁻¹ (CL_Cr= 80 ml min⁻¹), (D) 200 mg day⁻¹ (CL_Cr= 60 ml min⁻¹), (E) 150 mg day⁻¹ (CL_Cr= 40 ml min⁻¹) and (F) 100 mg day⁻¹ (CL_Cr= 20 ml min⁻¹) according to current allopurinol dosing guidelines [16]. The dashed line represents the minimum recommended target plasma oxypurinol concentration 15.2 −22.8 mg l⁻¹