Table 1.

Blood and plasma biochemical parameters at sacrifice

	CON+SH	CON+PO	HF+SH	HF+PO	DIA+SH	DIA+PO
Glucose (mmol/l)	3.6 ± 0.1	3.1 ± 0.4	4.0 ± 0.3	4.2 ± 0.2	10.3 ± 0.6 †‡	11.2 ± 1.2 †‡
HbA1c (%)	3.29 ± 0.05	3.30 ± 0.04	3.45 ± 0.05	3.47 ± 0.07	6.24 ± 0.17 †‡	6.33 ± 0.10 †‡
Triglycerides (mg/dl)	92 ± 14	83 ± 13	92 ± 11	102 ± 11	231 ± 44 †‡	311 ± 63 †‡
Cholesterol (mg/dl)	68 ± 9	75 ± 7	72 ± 9	90 ± 6	52 ± 4	61 ± 7 ‡
Renal function
Kidney wt/TL (mg/mm)	28.9 ± 1.0	27.7 ± 1.0	30.9 ± 1.2	29.6 ± 1.0	38.1 ± 1.2 †‡	40.4 ± 2.3 †‡
Creatinine (mg/dl)	0.42 ± 0.03	0.43 ± 0.03	0.37 ± 0.02	0.36 ± 0.06	0.48 ± 0.01	0.46 ± 0.02
Blood urea nitrogen (mg/dl)	13.5 ± 1.5	14.1 ± 0.9	11.2 ± 0.4	10.6 ± 1.7	21.9 ± 2.8 †‡	20.2 ± 1.5 †‡
Pancreatic function
Amylase (U/l)	477 ± 91	662 ± 33 *	655 ± 78 †	674 ± 64	510 ± 30	496 ± 18
Liver function
Alanine aminotransferase (U/l)	28.7 ± 6.2	32.6 ± 3.6	30.8 ± 3.2	34.3 ± 4.4	50.5 ± 3.2 †‡	48.8 ± 3.6 ‡
Bilirubin (mg/dl)	0.21 ± 0.01	0.20 ± 0.03	0.19 ± 0.02	0.31 ± 0.05	0.34 ± 0.04 ‡	0.36 ± 0.05 †

Values are mean ± SEM. CON, control diet; HF, high fat diet; DIA, diabetic; SH, sham surgery; PO, pressure overload surgery; TL, tibia length.

^*P<0.05 vs respective Sham group;

^†P<0.05 vs respective Control group;

^‡P<0.05 vs respective High fat group.