Skip to main content
. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Mech Dev. 2012 Jun 15;129(9-12):308–323. doi: 10.1016/j.mod.2012.06.002

Figure 10. Expression of genes expressed in the lateral crista is altered in Chd7 mutant embryos.

Figure 10

In situ hybridization (A, D-G, J-M, P-S, V-X) or immunofluorescence (B, C, H, I, N, O, T, U) of E11.5 transverse sections at the level of the lateral canal. Bmp4, JAG1, SOX2, Gata3, Lmo4 and Msx1 are present within the lateral crista primordium (lc) in conditional heterozygous mutants (G-L), but absent from CKO otocysts (* in S-X). Bmp4 expression is variably absent in Chd7Gt/flox otocysts (* in M), but JAG1 and SOX2 are preserved in adjacent sections (N, O). Expression of Gata3 and Lmo4 are unchanged in Chd7Gt/flox otocysts (P,Q), but lateral expression of Msx1 is absent (* in R). Bold lines delineate expression domains. Abbreviation: CKO= Chd7 conditional knockout (Foxg1-Cre;Chd7Gt/flox).