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. Author manuscript; available in PMC: 2012 Oct 21.
Published in final edited form as: Biomark Med. 2011 Dec;5(6):715–729. doi: 10.2217/bmm.11.87

Figure 1. Nuclear reprogramming transforms the mitochondrial infrastructure.

Figure 1

Nuclear reprogramming induces reorganization of cytosolic mitochondrial network of fibroblasts (A) into few perinuclear-localized mitochondria in mouse-derived iPS cells (B). This organization is consistent with natural pluripotent stem cell properties, and has been implicated as a marker of stemness. Higher magnification micrographs display regression of tubular and cristae-rich mitochondria (C) into spherical and cristae-poor remnants (D) during derivation of iPS cells. Original micrographs were obtained on a JEOL 1200 EXII electron microscope from ultramicrotome sections of glutaraldehyde and formaldehyde fixed cells.

iPS: Induced pluripotent stem.