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. Author manuscript; available in PMC: 2013 Sep 28.
Published in final edited form as: Cell. 2012 Sep 28;151(1):96–110. doi: 10.1016/j.cell.2012.08.034

Figure 6. Trpv4−/− mice are protected from obesity, adipose inflammation and metabolic dysfunction with exposure to high fat diet.

Figure 6

(A) Body composition in WT and Trpv4−/− mice. (B) Energy expenditure (as oxygen consumption) after 7 weeks HFD. (C) mRNA expression of macrophage markers. (D) H&E staining of EPI fat after 16 weeks of HFD, arrows indicates “crown like structures” (E) Western blot analysis of PPARγ serine-273 phosphorylation in EPI fat. (F) Tnfa mRNA expression in EPI fat. (G) Fasting and glucose (1g/kg) stimulated insulin levels. (H) IP-glucose tolerance test (1.0g/kg) and (I) IP-insulin tolerance test (1U/kg) in WT and Trpv4−/− mice after 12 weeks HFD. Data are presented as mean ± sem. See also Figure S6.