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(A) Tegaserod (1 μmol/L) caused a significant increase in ISC that was blocked by the 5-HT4R antagonist, GR113808 (1 μmol/L), and by neural blockade with TTX (0.3 μmol/L). (B) Serosal application of tegaserod did not alter the ISC. (C) No response was detected by mucosal application of tegaserod in the duodenum. ***P < .001 vs vehicle; †P < .001 vs tegaserod (n = 6).
