Table 2.

Body weights and relative liver weights in dams and female offspring in the early-life effects cross-foster study.

	PND 1		PND 3		PND 5		PND 10
	Body weight (g)	Relative liver weight	Body weight (g)	Relative liver weight	Body weight (g)	Relative liver weight	Body weight (g)	Relative liver weight
Dam
Control, control pups	37.4 ± 1.7	6.5 ± 0.4	39.5 ± 1.6	6.4 ± 0.1	41.8 ± 1.2	6.9 ± 0.2	45.3 ± 0.9	7.2 ± 0.2
Control, treated (5U) pups	33.9 ± 1.2	6.1 ± 0.3	39.1 ± 2.5	6.1 ± 0.1	38.0 ± 1.8	7.2 ± 0.2	42.6 ± 0.9	7.6 ± 0.2
Treated, control (5L) pups	38.2 ± 0.4	12.0 ± 0.4*	37.3 ± 2.8	13.4 ± 0.4*	43.7 ± 0.7	13.1 ± 0.2*	46.4 ± 1.5	10.2 ± 0.5*
Treated, treated (5U + L) pups	37.4 ± 2.1	12.5 ± 0.7*	41.2 ± 1.1	14.1 ± 0.5*	43.3 ± 2.2	12.6 ± 0.4*	48.2 ± 1.3	12.9 ± 0.2*
Female pups
Control	1.77 ± 0.06	4.1 ± 0.2	2.29 ± 0.10	3.3 ± 0.1	3.65 ± 0.10	3.0 ± 0.1	6.07 ± 0.29	2.7 ± 0.02
5U pups	1.65 ± 0.01	6.8 ± 0.1*	2.07 ± 0.10	6.6 ± 0.1*	2.73 ± 0.13*	6.1 ± 0.3*	4.51 ± 0.09*	5.8 ± 0.1*
5L pups	1.69 ± 0.04	4.4 ± 0.2	2.25 ± 0.13	3.6 ± 0.2	3.03 ± 0.11*	3.9 ± 0.3*	5.64 ± 0.08*	4.3 ± 0.1*
5U + L pups	1.60 ± 0.06	6.9 ± 0.2*	1.85 ± 0.05*	6.8 ± 0.1*	2.43 ± 0.11*	6.0 ± 0.1*	4.34 ± 0.09*	6.4 ± 0.2*

Note. Data presented are mean ± S.E. The relative liver weight means are calculated as the average of each dam’s liver weight divided by their body weight, multiplied by 100. Pup body weight means are calculated as the average of the litter averages (of 3 female pups). As with pup body weight means, relative liver weight means were calculated by averaging the litter averages for relative liver weight. N = 4 dams or litters (N = 3 female pups per litter) per treatment group per time point for the early-life effects cross-foster study. N = 9–18 adult females per treatment group per time point for the late-life effects cross-foster study.

^*Significant treatment effect compared to control; p < 0.05.