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. 2012 Oct 11;2012:483123. doi: 10.1155/2012/483123

Figure 6.

Figure 6

EA blunts zymosan-induced ERK1and ERK2 activation. ERK1 and ERK2 activation is presented by phosph-ERK1 and ERK2 versus their related total ERK1 and ERK2. ERK1 and ERK2 activation is slightly induced by EA in group S + A, while it is dramatically induced by zymosan injection. Zymosan-induced ERK1 and ERK2 activation is obviously compromised by EA in colorectum (P < 0.001), spinal cord (P < 0.05), and hypothalamus (P < 0.001). EA in alleviating hypersensitivity is probably associated with external signaling (p-ERK1/2: #9109, cell signaling, 42/44 KD, delusion: 1 : 2000; ERK1/2: #4695, cell signaling, 42/44 KD, delusion: 1 : 2000).