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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Gastroenterology. 2011 Dec 7;142(3):531–542. doi: 10.1053/j.gastro.2011.11.034

Figure 5.

Figure 5

Lost KLF4 expression and FoxM1 overexpression in gastric tumors. (A) Western blot analyses were performed using total protein lysates extracted from antral mucosa in mice at the ages of 35 (A1), 50 (A2), and 80 (A3) weeks and from antral tumors (A4). KLF4+/+, Villin-Cre−;Klf4fl/fl; KLF4+/−, Villin-Cre+;Klf4+/fl; KLF4−/−, Villin-Cre+;Klf4fl/fl. (B) Immunohistochemical staining for KLF4 (upper panels) and FoxM1 (lower panels) protein. From left to right were: normal, hyperplastic, intramucosal neoplastic, and neoplastic tissue from mice at age of 80 weeks. (C) Immunohistochemical staining of two gastric tumors for KLF4 and FoxM1 protein from mice at age of 80 weeks. The right panels are views of the middle panels at higher magnification.

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