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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Aug 9;22(19):6233–6236. doi: 10.1016/j.bmcl.2012.08.010

Scheme 1.

Scheme 1

Reagents: (a) LiAlH4, THF, 67%; (b) a-bromoisobutyrate, KOH, EtOH, 94%; (c) PPh3, C2Cl6, 95%; (d) KCN, BH3.THF, 78%; (e) 4-cyclohexyl-1-bromobutane, DIPEA, 68%; (f) 2/3/4-methoxyphenylisocyanate, TFA. Yields: KSM-03, 65%; KSM-02, 85%; KSM-01, 90%.