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. 2012 Oct 22;3:298. doi: 10.3389/fimmu.2012.00298

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Copyright © 2012 Recchiuti and Serhan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Evidence for ALX/FPR2-RvD1-dependent miRNA pathways in vivo. Reduction in (A) PMN infiltration by RvD1 is significantly higher in myeloid-driven human ALX-transgenic (Tg) mice challenged with zymosan (1 mg/mouse, i.p., 24 h) than non-Tg littermates. Results are mean ± SEM from three mice/group (*P < 0.05 vs. non-Tg). (B) Relative expression of miR-208a determined in resolving exudates 24 h after zymosan alone or zymosan plus RvD1 administration in hALX-Tg or non-Tg littermates (mean ± SEM, n = 3 mice/group; **P < 0.05 vs. non-Tg zymosan group; #, P < 0.05 vs. hALX-Tg zymosan group). (C) miR-208a expression in peritoneal exudates (24 h) from ALX/FPR2 knockout mice treated with zymosan alone or zymosan plus RvD1.