Figure 2. Morphological- and physiological-disease genes enriched in different disease classes.

(a) Morphological and physiological human disease genes were classified by mapping mouse phenotypic alterations taken from the MGI database; the database describes 5,199 mouse genes that have one or more phenotypic alterations; morphological, physiological, and both; caused by knockout, knockdown, or other mutations. (b) Morphological and physiological human disease genes are enriched differently in various human disease classes. The intensity of color indicates the significance of enrichment (hypergeometric P-values).