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A and B, simulation of the action of 5 mm caesium and 3 μm ivabradine according to our SAN cell model. C, voltage dependence of If block by 5 mm Cs+ used in our model to simulate the action of Cs+, as based on DiFrancesco et al.'s (1986) data (open circles). D, experimental result with 1 μm ivabradine from DiFrancesco (2010). E, simulated effect of 66% block of If current in the ML model.
