Table 1.
Quantitative summary of the effects of KCNQ1 (S140G) mutation on human atrial electrical activity
| Model | Quantity | Con (ϕ= 0) | MT (ϕ= 0.1) | MT (ϕ= 0.25) | MT (ϕ= 1) |
|---|---|---|---|---|---|
| Cell | Resting potential (mV) | −80.80 | −80.01 | −78.74 | −76.88 |
| APD (ms) | 314.2 | 147.5 | 79.3 | 22.4 | |
| Overshoot (mV) | 24.61 | 24.07 | 23.05 | 18.11 | |
| dV/dtmax (mV ms−1) | 217.10 | 214.17 | 208.58 | 193.44 | |
| APDr maximal slope | 1.3 | 0.6 | 0.38 | 0.05 | |
| ERP (ms) (stimulus interval ∼1 s) | 319.6 | 169.1 | 109.5 | 56.0 | |
| 1D | CV (mm ms−1) | 0.27 | 0.27 | 0.27 | 0.258 |
| VW (ms) | 3.22 | 3.36 | 3.25 | 3.22 | |
| Wavelength (mm) | 84.84 | 36.99 | 21.42 | 5.29 | |
| 2D | LS (s) | 1.42 | >10 | >10 | >10 |
| DF (Hz) | 3.5 | 7.1 | 9.8 | 16.1 | |
| Tip meander area (cm2) | 10.63 | 1.10 | 0.58 | 0.32 | |
| MS (mm) | 49.6 | 7.45 | 6.15 | 0.6 | |
| 3D | LS (s) | 4.2 | >6 | — | — |
| DF (Hz) | 3.1 | 8.9 | — | — |