Table 3.

Summary of parameter sensitivity results at the whole organ level

	Ejection	Peak SP	ESP	SV
PV data	43 ms	11.8 kPa	6.9 kPa	28.8 μl
Default	27.3 ms	16.0 kPa	11.3 kPa	38.5 μl
Whole-organ parameters
C2−12.5%	↑ 0.3 ms	↑ 0.3 kPa	↑ 0.1 kPa	↑ 1.9 μl
C4+370%	↓ 0.5 ms	↑ 0.3 kPa	↑ 0.1 kPa	↑ 1.1 μl
edp+0.1 kPa	↑ 0.5 ms	↑ 0.4 kPa	↑ 0.1 kPa	↑ 2.6 μl
pa+1 kPa	↑ 0.1 ms	↑ 0.5 kPa	⇑ 0.7 kPa	↓ 1.8 μl
R−50%	↑ 0.1 ms	↓ 0.1 kPa	↓ 0.4 kPa	↑ 0.5 μl
Z+50%	⇑ 3.8 ms	⇑ 1.3 kPa	↓ 0.3 kPa	↓ 2.6 μl
C−50%	=	↑ 0.5 kPa	⇑ 1.6 kPa	⇓ 4.6 μl
Cellular parameters
β0–50%	↑ 0.1 ms	↑ 0.2 kPa	=	↑ 2.4 μl
β1–50%	⇑ 2.5 ms	↓ 0.5 kPa	↓ 0.1 kPa	↓ 0.2 μl
Tref−20 kPa	↑ 1.3 ms	⇓ 1.3 kPa	↓ 0.5 kPa	⇓ 5.2 μl
A1=−29	⇑ 10.8 ms	⇓ 2.7 kPa	↓ 0.5 kPa	⇓ 4.9 μl
a+50%	↑ 0.5 ms	↓ 0.2 kPa	↓ 0.1 kPa	=

Results shown for duration of ejection, peak systolic pressure (SP), end systolic pressure (ESP) and stroke volume (SV). The magnitude of parameter variation is based on how constrained it is given available data, and generally taken in the direction to increase duration of ejection. See Tables S1 and S2 in the Supplemental Material for detailed results.