Table 3.
A univariate analysis of risk factors for late significant (at least mild-moderate) TR.
| Risk factor | No TR/mild TR n = 140 |
At least mild-moderate TR n = 23 |
P value | |
|---|---|---|---|---|
| Number of EMBs | Average total number of EMBs taken | 17.5 ± 5.9 | 20.7 ± 6.5 | 0.045 |
| Average number of EMBs taken before TR development | 17.5 ± 5.9 | 15.7 ± 9.1 | 0.431 | |
|
| ||||
| Number of ACRs* | Median number of ACRs ≥ grade 1R** | 6 (0–24) | 7 (2–23) | 0.087 |
| Median number of ACRs ≥ grade 2R** | 0 (0–7) | 1 (0–8) | 0.712 | |
|
| ||||
| Average MPAP (mmHg) | 36.8 ± 13.7 | 47.0 ± 12.9 | 0.064 | |
| Pre-transplant hemodynamic parameters | Average PVR (Wood units) | 3.3 ± 2.2 | 5.1 ± 3.0 | 0.070 |
| Average right atrial pressure (mmHg) | 11.4 ± 6.5 | 14.8 ± 7.2 | 0.280 | |
|
| ||||
| Surgical technique employed | Biatrial % | 34.4% | 65% | 0.009 |
|
| ||||
| Any CAV |
33.8% | 76.2% | <0.001 | |
| Cardiac allograft vasculopathy | Significant CAV |
25.4% | 71.4% | <0.001 |
| 2 or 3 vessels CAV |
18.5% | 57.1% | <0.001 | |
TR: tricuspid regurgitation; EMBs: endomyocardial biopsies; ACRs: acute cellular rejections; MPAP: mean pulmonary arterial pressure; PVR: pulmonary vascular resistance; CAV: cardiac allograft vasculopathy.
*Data are presented as median and range (min–max).
**According to the revised ISHLT criteria.