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. Author manuscript; available in PMC: 2013 Oct 17.
Published in final edited form as: Bioconjug Chem. 2012 Sep 26;23(10):1989–2006. doi: 10.1021/bc3003309

Figure 5.

Figure 5

Clinical imaging with cell death molecular probes. (A) Scintigraphic images of separate non-treated and drug treated breast cancer patients who were injected with 99mTc-EC-Annexin V. Annexin V had higher accumulation in treated breast tumors compared to non-treated tumors, though the probe localized to both tumors as indicated by the cross-lines. (B) 18F-ML-10 PET images of a brain metastasis in a single patient (indicated by arrow) before and after whole brain radiation therapy. The low level of 18F-ML-10 accumulation in the metastasis prior to treatment likely represents a basal amount of cell death. Reprinted with permission from references 89 and 147.