TABLE II.

CASE-CONTROL DISTRIBUTION OF GENOTYPES OF 11 POTENTIAL ATM SEQUENCE VARIANTS

	Reference	Position	Genotypes	Cases, N (%)	Controls, N (%)	OR1 (95% CI1)2	HWE3 p (controls)
ATM01	rs228589	5′ region	AA + AT	434 (80.7)	433 (80.8)	1.00 (reference)	0.31
			TT	104 (19.3)	103 (19.2)	1.01 (0.74–1.37)
ATM02	rs664677	Intron	TT + TC	445 (81.4)	441 (81.7)	1.00 (reference)	0.34
			CC	102 (18.6)	99 (18.3)	1.03 (0.81–1.14)
ATM03	rs1800058	Exon, nsSNP4	CC + CT	549 (99.8)	550 (100)	1.00 (reference)	0.60
			TT	1 (0.2)	0 (0)	N/A5
ATM04	rs1800889	Exon, sSNP4	CC + CT	548 (100)	550 (99.8)	1.00 (reference)	0.80
			TT	0 (0)	1 (0.2)	N/A
ATM05	rs1801516	Exon, nsSNP	GG + GA	537 (98.7)	536 (98.2)	1.00 (reference)	0.59
			AA	7 (1.3)	10 (1.8)	0.70 (0.26–1.85)
ATM06	rs611646	Intron	TT + TA	445 (81.4)	458 (85.0)	1.00 (reference)	0.18
			AA	102 (18.6)	81 (15.0)	1.30 (0.95–1.80)
ATM07	rs609429	Intron	GG + GC	436 (80.9)	438 (81.4)	1.00 (reference)	0.25
			CC	103 (19.1)	100 (18.6)	1.04 (0.76–1.41)
ATM08	rs227060	Intron	CC + CT	469 (88.7)	495 (92.4)	1.00 (reference)	0.02
			TT	60 (11.3)	41 (7.6)	1.55 (1.02–2.35)
ATM09	rs664143	Intron	GG + GA	433 (80.6)	441 (82.3)	1.00 (reference)	0.16
			AA	104 (19.4)	95 (17.7)	1.12 (0.82–1.52)
ATM10	rs170548	Intron	AA + AC	483 (89.3)	500 (92.6)	1.00 (reference)	0.04
			CC	58 (10.7)	40 (7.4)	1.51 (0.99–2.31)
ATM11	rs4585	3′ region	TT + TG	442 (80.8)	440 (81.5)	1.00 (reference)	0.14
			GG	105 (19.2)	100 (18.5)	1.05 (0.77–1.42)

The bold type face indicates a significant results.

¹OR, odds ratio; CI, confidence interval.

²Adjusted for age, gender and smoking status.

³HWE, Hardy–Weinberg equilibrium.

⁴nsSNP, non-synonymous SNP; sSNP, synonymous SNP.

⁵N/A, not available.