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. 2012 Oct 10;32(41):14087–14093. doi: 10.1523/JNEUROSCI.3242-12.2012

Table 1.

Nf1 genetically engineered mouse models of CNS dysfunction

GEM strain Description CNS abnormality References
Nf1+/− mice Mice with reduced Nf1 gene expression throughout Impaired learning, memory, and attention; increased astrogliosis Jacks et al., 1994; Silva et al., 1997; Gutmann et al., 1999; Rizvi et al., 1999
Nf1+/−Syn mice Mice with reduced Nf1 gene expression in hippocampal neurons Impaired learning, memory, and attention Cui et al., 2008
Nf1+/−GFAPCKO mice Nf1+/− mice with complete Nf1 loss in neuroglial progenitors Impaired learning, memory, and attention; optic glioma formation Brown et al., 2010a; Bajenaru et al., 2003
Nf1+/−; KRasGFAP mice Nf1+/− mice with KRas activation in neuroglial progenitors Optic glioma formation Dasgupta et al., 2005a
Nf1;p53GFAPCKO mice Mice with Nf1 and p53 inactivation in neuroglial progenitors High-grade glioma formation Zhu et al., 2005b
Nf1;p53; PtenGFAPCKO mice Mice with Nf1,p53, and Pten inactivation in neuroglial progenitors GBM formation Kwon et al., 2008
Nf1;p53; PtennestinCKO mice Mice with Nf1,p53, and Pten inactivation in neural stem cells GBM formation Chen et al., 2012