Table 1.

Nf1 genetically engineered mouse models of CNS dysfunction

GEM strain	Description	CNS abnormality	References
Nf1+/− mice	Mice with reduced Nf1 gene expression throughout	Impaired learning, memory, and attention; increased astrogliosis	Jacks et al., 1994; Silva et al., 1997; Gutmann et al., 1999; Rizvi et al., 1999
Nf1+/−Syn mice	Mice with reduced Nf1 gene expression in hippocampal neurons	Impaired learning, memory, and attention	Cui et al., 2008
Nf1+/−GFAPCKO mice	Nf1+/− mice with complete Nf1 loss in neuroglial progenitors	Impaired learning, memory, and attention; optic glioma formation	Brown et al., 2010a; Bajenaru et al., 2003
Nf1+/−; KRasGFAP mice	Nf1+/− mice with KRas activation in neuroglial progenitors	Optic glioma formation	Dasgupta et al., 2005a
Nf1;p53GFAPCKO mice	Mice with Nf1 and p53 inactivation in neuroglial progenitors	High-grade glioma formation	Zhu et al., 2005b
Nf1;p53; PtenGFAPCKO mice	Mice with Nf1,p53, and Pten inactivation in neuroglial progenitors	GBM formation	Kwon et al., 2008
Nf1;p53; PtennestinCKO mice	Mice with Nf1,p53, and Pten inactivation in neural stem cells	GBM formation	Chen et al., 2012